Gastrointestinal diseases

Definition

Gastrointestinal diseases are those that affect any section of the gastrointestinal tract, from the oesophagus to the rectum, and the accessory digestive organs – liver, gall bladder and pancreas. The term encompasses acute, chronic, recurrent or functional disorders and covers a wide range of diseases, including inflammatory bowel disease and functional dyspepsia.

Featured

Latest Research and Reviews

  • Research |

    Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation.

    • Kevin P O'Rourke
    • , Evangelia Loizou
    • , Geulah Livshits
    • , Emma M Schatoff
    • , Timour Baslan
    • , Eusebio Manchado
    • , Janelle Simon
    • , Paul B Romesser
    • , Benjamin Leach
    • , Teng Han
    • , Chantal Pauli
    • , Himisha Beltran
    • , Mark A Rubin
    • , Lukas E Dow
    •  & Scott W Lowe
    Nature Biotechnology

  • Research |

    Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.

    • Jatin Roper
    • , Tuomas Tammela
    • , Naniye Malli Cetinbas
    • , Adam Akkad
    • , Ali Roghanian
    • , Steffen Rickelt
    • , Mohammad Almeqdadi
    • , Katherine Wu
    • , Matthias A Oberli
    • , Francisco Sánchez-Rivera
    • , Yoona K Park
    • , Xu Liang
    • , George Eng
    • , Martin S Taylor
    • , Roxana Azimi
    • , Dmitriy Kedrin
    • , Rachit Neupane
    • , Semir Beyaz
    • , Ewa T Sicinska
    • , Yvelisse Suarez
    • , James Yoo
    • , Lillian Chen
    • , Lawrence Zukerberg
    • , Pekka Katajisto
    • , Vikram Deshpande
    • , Adam J Bass
    • , Philip N Tsichlis
    • , Jacqueline Lees
    • , Robert Langer
    • , Richard O Hynes
    • , Jianzhu Chen
    • , Arjun Bhutkar
    • , Tyler Jacks
    •  & Ömer H Yilmaz
    Nature Biotechnology

  • Research | | open

    The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and induces Sox9 to expand the Paneth cell compartment and enrich the ISC niche.

    • Lingling Xian
    • , Dan Georgess
    • , Tait Huso
    • , Leslie Cope
    • , Amy Belton
    • , Yu-Ting Chang
    • , Wenyong Kuang
    • , Qihua Gu
    • , Xiaoyan Zhang
    • , Stefania Senger
    • , Alessio Fasano
    • , David L. Huso
    • , Andrew J. Ewald
    •  & Linda M. S. Resar
    Nature Communications 8, 15008

  • Research | | open

    Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

    • Jun Fang
    • , Jinping Jia
    • , Matthew Makowski
    • , Mai Xu
    • , Zhaoming Wang
    • , Tongwu Zhang
    • , Jason W. Hoskins
    • , Jiyeon Choi
    • , Younghun Han
    • , Mingfeng Zhang
    • , Janelle Thomas
    • , Michael Kovacs
    • , Irene Collins
    • , Marta Dzyadyk
    • , Abbey Thompson
    • , Maura O’Neill
    • , Sudipto Das
    • , Qi Lan
    • , Roelof Koster
    • , PanScan Consortium
    • , Federico Canzian
    • , Charles Kooperberg
    • , Zhaoming Wang
    • , Alan A Arslan
    • , Paige M Bracci
    • , Julie Buring
    • , Eric J Duell
    • , Steven Gallinger
    • , Eric J Jacobs
    • , Aruna Kamineni
    • , Stephen Van Den Eeden
    • , Alison P Klein
    • , Laurence N Kolonel
    • , Donghui Li
    • , Sara H Olson
    • , Harvey A Risch
    • , Howard D Sesso
    • , Kala Visvanathan
    • , Wei Zheng
    • , Demetrius Albanes
    • , Melissa A Austin
    • , Marie-Christine Boutron-Ruault
    • , H Bas Bueno-de-Mesquita
    • , Michelle Cotterchio
    • , J Michael Gaziano
    • , Edward L Giovannucci
    • , Michael Goggins
    • , Myron Gross
    • , Manal Hassan
    • , Kathy J Helzlsouer
    • , Elizabeth A Holly
    • , David J Hunter
    • , Mazda Jenab
    • , Rudolf Kaaks
    • , Timothy J Key
    • , Kay-Tee Khaw
    • , Vittorio Krogh
    • , Robert C Kurtz
    • , Andrea LaCroix
    • , Loic Le Marchand
    • , Satu Mannisto
    • , Alpa V Patel
    • , Petra H M Peeters
    • , Elio Riboli
    • , Xiao-Ou Shu
    • , Malin Sund
    • , Mark Thornquist
    • , Anne Tjønneland
    • , Geoffrey S Tobias
    • , Dimitrios Trichopoulos
    • , Jean Wactawski-Wende
    • , Herbert Yu
    • , Kai Yu
    • , Anne Zeleniuch-Jacquotte
    • , Robert Hoover
    • , Patricia Hartge
    • , Charles Fuchs
    • , Stephen J Chanock
    • , TRICL Consortium
    • , Victoria Stevens
    • , Demetrios Albanes
    • , Neil E Caporaso
    • , Paul Brennan
    • , James McKay
    • , Xifeng Wu
    • , Rayjean J Hung
    • , John R McLaughlin
    • , Heike Bickeboller
    • , Angela Risch
    • , Erich Wichmann
    • , Richard Houlston
    • , GenoMEL Consortium
    • , Graham Mann
    • , John Hopper
    • , Joanne Aitken
    • , Bruce Armstrong
    • , Graham Giles
    • , Elizabeth Holland
    • , Richard Kefford
    • , Anne Cust
    • , Jennifer H. Barrett
    • , Amaury Vaysse
    • , Coby Out
    • , Susana Puig
    • , Miriam Potrony
    • , Wilma Bergman
    • , Tadeusz Debniak
    • , Mark M. Iles
    • , Pascal W. T. C. Jansen
    • , Cristina Carrera
    • , Alisa M Goldstein
    • , Valerie Chaudru
    • , Marie-Francoise Avril
    • , Luc Thomas
    • , Veronica Hoiom
    • , Marinus van Praag
    • , Giorgi Landi
    • , Stuart Mac Gregor
    • , Nelleke Gruis
    • , Gemma Tell Marti
    • , Myriam Bossard
    • , Josep Malvehy
    • , Fabio Arcangeli
    • , Patricia Jeannin
    • , Christopher I. Amos
    • , Hans Vasen
    • , Grant Montgomery
    • , Mark Harland
    • , Florence Demenais
    • , Christian Ingvar
    • , Montse Mila
    • , Eva Wierzbicka
    • , Dominique Leroux
    • , Jeremie Nsengimana
    • , John Davies
    • , Lars A Akslen
    • , Virginia Andreotti
    • , Jo Gascoyne
    • , Bart Janssen
    • , Alon Scope
    • , Joan-AntonPuig Batille
    • , Srdjan Novakovic
    • , Brian M. Wolpin
    • , Jon Laye
    • , Peter Kraft
    • , Francoise Boitier
    • , Goran Jonsson
    • , Dyon Snels
    • , Hakan Olsson
    • , Nandita Mitra
    • , Paola Queirolo
    • , David Whiteman
    • , Sara Olson
    • , Bert Bakker
    • , Lorenze Pastorino
    • , Caroline Robert
    • , Juliette Randerson-Moor
    • , Celia Badenas
    • , Ake Borg
    • , William Bruno
    • , Marko Hocevar
    • , Katherine A. McGlynn
    • , Esther Azizi
    • , Ludovic Martin
    • , May Chan
    • , Thorkell Andresson
    • , Fabienne Lesueur
    • , Stephane Dalle
    • , Frederic Caux
    • , Jan Lubinski
    • , Irit Cohen-Manheim
    • , Han van der Rhee
    • , Julie Lang
    • , Eitan Freidman
    • , David Elder
    • , Per Helsing
    • , Eve Maubec
    • , Johan Hansson
    • , Orna Baron-Epel
    • , Barbara Peric
    • , Maria Teresa Landi
    • , Laufey T. Amundadottir
    • , Francesco Spagnolo
    • , Lieve Brochez
    • , Paula Aguilera
    • , Marianne Crijns
    • , Kari Nielsen
    • , Per Arne Andresen
    • , Kevin M. Brown
    • , Rianne Gerritsen
    • , Oliver Caron
    • , Dominique Stoppa-Lyonnet
    • , Rachael S. Stolzenberg-Solomon
    • , Peter A. Kanetsky
    • , Gloria M. Petersen
    • , Marcel Bekkenk
    • , Oliviier Dereure
    • , Petra Skerl
    • , Helen Schmid
    • , Julia A. Newton-Bishop
    • , Michiel Vermeulen
    • , Jan Nico Bouwes Bavinck
    • , Nicholas Martin
    • , Margaret A Tucker
    • , Hamida Mohamdi
    • , Christine Mateus
    • , Anita Schmidt Zander
    • , Nick Hayward
    • , Pablo Iglesias-Garcia
    • , Sally O'Shea
    • , Yael Laitman
    • , John C. Taylor
    • , David Duffy
    • , Alicia Barreiro
    • , Pol Gimenez Xavier
    • , Frans A van Nieuwpoort
    • , Pier Alberto Bertazzi
    • , Donato Calista
    • , Katherine L. Nathanson
    • , Xiaohong R Yang
    • , Rona Mackie
    • , Felix Pavlotsky
    • , Alison M. Dunning
    • , Paola Ghiorzo
    • , Ramon Pigem
    • , Nilanjan Chatterjee
    • , Daniel Gabriel
    • , D. Timothy Bishop
    • , Anders Molvern
    • , Mark Jenkins
    • , Paola Minghetti
    • , Brigitte Bressac-de Paillerets
    • , Michael Ming
    • , Jeanet ter Huurne
    • , Helge Rootwelt
    • , Nienke van der Stoep
    • , Nicole Kukutsch
    • , Giovanna Bianchi Scarra
    •  & Katja Harbst
    Nature Communications 8, 15034
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