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Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults.
The disease exhibits a striking heterogeneity in gene expression profiles and clinical
outcomes, but its genetic causes remain to be fully defined. Through whole genome
...
Contemporary high-throughput technologies permit the rapid identification of transcription
factor (TF) target genes on a genome-wide scale, yet the functional significance of
TFs requires knowledge of target gene expression patterns, cooperating TFs, and ...
Mixed-lineage leukemia (MLL) fusions are potent oncogenes that initiate aggressive forms of acute leukemia. As
aberrant transcriptional regulators, MLL-fusion proteins alter gene expression in
hematopoietic cells through interactions with the histone H3 ...
Alternative polyadenylation (APA) plays an important role in posttranscriptional gene
regulation such as transcript stability and translation efficiency. However, our knowledge
about APA dynamics at the single-cell level is largely unexplored. Here, we ...