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Immunology news
HIV & AIDS
A plant-based compound that inhibits reactivation of the HIV viral reservoir, giving the immune system a break
As of 2022, approximately 1.2 million people in the United States are living with HIV. Antiretroviral therapies have enabled many of these individuals to live productive, symptom-free lives, but a cure that permanently eliminates ...
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Oncology & Cancer
Investigators identify potential new targets to overcome treatment resistance in aggressive breast cancer
Researchers with the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborators have shown that immature natural killer (NK) cells are present in patients with triple-negative ...
7 hours ago
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Study: Keeping T cells active, but not too active, could be key to new immune therapies
While T cells play a critical role in the immune system by protecting the body against infection and cancer, regulation of T cell activity is necessary to prevent excessive inflammation and damage to healthy tissue.
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Cancer that spreads to the lung maneuvers to avoid being attacked by 'killer' T cells
Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.
11 hours ago
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CPEB4 protein is essential for maintaining the antitumor function of T lymphocytes, reveals study
T lymphocytes are components of the immune system that are located in the tumor environment. They serve to identify and remove tumor cells. In order to perform this function, they must produce a large amount of secreted proteins, ...
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Researchers discover new autoinflammatory disease, suggest target for potential treatments
Scientists have identified an autoinflammatory disease caused by mutations in the LYN gene, an important regulator of immune responses in health and disease. Named Lyn kinase-associated vasculopathy and liver fibrosis (LAVLI), ...
6 hours ago
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New insights into HIV reservoirs and prospects for remission
Researchers associated with the AIDS Clinical Trials Group (ACTG) have published a study titled "Varied Patterns of Decay of Intact HIV-1 Proviruses over Two Decades of ART" in the Journal of Infectious Diseases.
23 hours ago
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Researchers discover two-pronged approach to stimulate STING antitumor activity
Immunotherapies have greatly improved the outcomes of many patients with melanoma. But there is still a need for new approaches for the subset of patients who do not respond well to this type of therapy. Moffitt Cancer Center ...
Mar 27, 2023
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HIV genomes that hide in white blood cells offer new target to eliminate infections
To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men ...
Mar 27, 2023
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Could the common cold give children immunity against COVID? Our research offers clues
Why children are less likely to become severely ill with COVID compared with adults is not clear. Some have suggested that it might be because children are less likely to have diseases, such as type 2 diabetes and high blood ...
Mar 27, 2023
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Cancer cells with thicker glycocalyx barrier are better at evading immune cells
One of the ways that cancer cells hide from the body's immune system is by forming a thin surface barrier called the glycocalyx. In a new study, researchers examined the material properties of this barrier with unprecedented ...
Mar 27, 2023
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Researchers identify cell type that could be key to preventing marrow transplant complication
A bone marrow transplant can be a lifesaving treatment for people with relapsed blood cancers, but a potentially lethal complication known as graft-versus-host disease put limitations on this procedure. New research from ...
Mar 24, 2023
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Study shows how cancer gene tricks immune cells
Cancer-associated genes called oncogenes are well known to stimulate cell growth and division—causing tumors to balloon and spread. But now, researchers at the Stanford School of Medicine and Sarafan ChEM-H have found that ...
Mar 24, 2023
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Getting around muscle aging by modulating the function of immune cells
Muscle is able to regenerate through a process that involves multiple steps and players, including the immune system. As our organism ages, the muscles lose the capacity to regenerate.
Mar 23, 2023
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Study shows how intestinal bacteria trigger complications after surgery
Nearly 16 million operations were performed on inpatients in German hospitals in 2021. In Switzerland, the figure is around 1.1 million. Even if the actual operation goes well, it is not uncommon for a wound infection to ...
Mar 23, 2023
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Researchers identify two enzymes involved in macrophage polarization in kidney fibrosis
Researchers at Nagoya University in Japan have identified two enzymes that are involved in macrophage polarization, one of the key factors affecting fibrosis. The group's findings, reported in Cell Death & Disease, suggest ...
Mar 23, 2023
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Ancient genomes reveal immunity adaptation in early farmers
Research from the Francis Crick Institute published today in Current Biology has revealed that diversity in genes coding for immunity may have facilitated adaptation to farming lifestyles in prehistoric periods.
Mar 23, 2023
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Study: COVID-19 mRNA booster vaccinations increased and sustained antibody responses
Booster vaccinations against SARS-CoV-2 are being promoted worldwide to counter the coronavirus disease 2019 (COVID-19) pandemic. Recent studies on the effectiveness of the third dose of the vaccine found improved efficacy ...
Mar 23, 2023
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Points to consider when using interferon assays
Interferons are type of protein called a cytokine. They have important roles in the immune system. Interferons are split into three distinct families—Type I, Type II, and Type III. Due to their role in autoimmunity, Type ...
Mar 23, 2023
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Research reveals molecular and cellular details of abdominal immune system
Because of the nature of organs like the stomach and liver in the abdominal cavity of mammals, infection can lead to life-threatening sepsis. A visceral adipose tissue called omentum helps cordon off any inflamed or injured ...
Mar 23, 2023
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